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Phenylpropanolamine (PPA)
Introduction
Phenylpropanolamine (PPA) is a synthetic sympathomimetic amine that acts primarily as a nasal decongestant and appetite suppressant. Structurally related to ephedrine and amphetamine, it stimulates the release of norepinephrine, resulting in vasoconstriction and reduced swelling of nasal tissues.
PPA was widely used in over-the-counter cold medications, weight loss products, and veterinary drugs. However, due to safety concerns—particularly its association with increased risk of hemorrhagic stroke—its use in human medicines has been banned or severely restricted in many countries, including the United States. Despite this, PPA remains in limited use for veterinary medicine, particularly for treating urinary incontinence in dogs.
Chemical Profile
Chemical Name: Phenylpropanolamine hydrochloride
Chemical Formula: C9H13NO·HCl



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